ABOUT US
The Mouse Cardiovascular Phenotyping Core was established in 1998 and currently performs more than 6,000 surgical and imaging procedures per year. The mouse core provides an experienced staff, which uses a focused systematic approach to studying the mouse circulatory system under basal and pathophysiologic conditions. To perform in-depth analysis of the mouse circulatory system in both normal and disease states, we have employed several state-of-the-art modalities including: an Acuson Sequoia cardiac echocardiography machine, a 1.4 French Millar catheter instrument system, an oxymax treadmill system which allows for measurements of respiratory exchange gases and a telemetric ambulatory ECG monitoring system. We also have a dedicated microsurgical operating room containing stereotactic surgical microscope, rodent ventilator and warming apparatus. In addition, we have rooms that allow overnight housing for telemetric monitoring and rooms solely used for echocardiography and exercise studies.
One
of the benefits of employing the Mouse Cardiovascular Phenotyping Core
is that we provide consistent results using validated techniques with
little experimental variation. Investigators can begin projects with knowledge
of the expected physiology and functional consequences in a variety of
mouse strains. We routinely meet with investigators to discuss experimental
design to help assess which procedure answers the proposed questions.
We are willing to tailor our skills to meet individual investigators'
needs. Services are available to all WU investigators as well as investigators
at other institutions. We welcome outside investigators and have extensive experience working with both industry and academic institutions outside
Center
for Cardiovascular Research
Washington University
School of Medicine