Publications

Wong NR, Mohan J, Kopecky BJ, Guo S, Du L, Leid J, Feng G, Lokshina I, Dmytrenko O, Luehmann H, Bajpai G, Ewald L, Bell L, Patel N, Bredemeyer A, Weinheimer CJ, Nigro JM, Kovacs A, Morimoto S, Bayguinov PO, Fisher MR, Stump WT, Greenberg M, Fitzpatrick JAJ, Epelman S, Kreisel D, Sah R, Liu Y, Hu H, Lavine KJ. Resident cardiac macrophages mediate adaptive myocardial remodeling. Immunity. Immunity. 2021 Sep 14;54(9):2072-2088.e7. doi: 10.1016/j.immuni.2021.07.003. Epub 2021 Jul 27.PMID: 34320366

Woo KV, Shen IY, Weinheimer CJ, Kovacs A, Nigro J, Lin CY, Chakinala M, Byers DE, Ornitz DM. Endothelial FGF signaling is protective in hypoxia-induced pulmonary hypertension. J Clin Invest. 2021 Sep 1;131(17):e141467. doi: 10.1172/JCI141467. PMID: 34623323; PMCID: PMC8409583.

Chambers KT, Cooper MA, Swearingen AR, Brookheart RT, Schweitzer GG, Weinheimer CJ, Kovacs A, Koves TR, Muoio DM, McCommis KS, Finck BN. Myocardial Lipin 1 knockout in mice approximates cardiac effects of human LPIN1 mutations. JCI Insight. 2021 May 10;6(9):e134340. doi: 10.1172/jci.insight.134340.PMID: 33986192

McCommis KS, Kovacs A, Weinheimer CJ, Shew TM, Koves TR, Ilkayeva OR, Kamm DR, Pyles KD, King MT, Veech RL, DeBosch BJ, Muoio DM, Gross RW, Finck BN. Nutritional modulation of heart failure in mitochondrial pyruvate carrier-deficient mice. Nat Metab. 2020 Nov;2(11):1232-1247. doi: 10.1038/s42255-020-00296-1. Epub 2020 Oct 26.PMID: 33106690

McClenaghan C, Huang Y, Matkovich SJ, Kovacs A, Weinheimer CJ, Perez R, Broekelmann TJ, Harter TM, Lee JM, Remedi MS, Nichols CG. The Mechanism of High-Output Cardiac Hypertrophy Arising From Potassium Channel Gain-of-Function in Cantú Syndrome. Function (Oxf). 2020;1(1):zqaa004. doi: 10.1093/function/zqaa004. Epub 2020 Jun 18.PMID: 32865539

Evans S, Weinheimer CJ, Kovacs A, Williams JW, Randolph GJ, Jiang W, Barger PM, Mann DL. Ischemia reperfusion injury provokes adverse left ventricular remodeling in dysferlin-deficient hearts through a pathway that involves TIRAP dependent signaling.Sci Rep. 2020 Aug 24;10(1):14129. doi: 10.1038/s41598-020-71079-7.PMID: 32839504

Javaheri A, Bajpai G, Picataggi A, Mani S, Foroughi L, Evie H, Kovacs A, Weinheimer CJ, Hyrc K, Xiao Q, Ballabio A, Lee JM, Matkovich SJ, Razani B, Schilling JD, Lavine KJ, Diwan A. TFEB activation in macrophages attenuates postmyocardial infarction ventricular dysfunction independently of ATG5-mediated autophagy. JCI Insight. 2019 Nov 1;4(21):e127312. doi: 10.1172/jci.insight.127312.PMID: 31672943

Rocha-Resende C, Weinheimer C, Bajpai G, Adamo L, Matkovich SJ, Schilling J, Barger PM, Lavine KJ, Mann DL. Immunomodulatory role of non-neuronal cholinergic signaling in myocardial injury. JCI Insight. 2019 Jun 4;5(14):e128961. doi: 10.1172/jci.insight.128961.PMID: 31162139

Ferey JLA, Boudoures AL, Reid M, Drury A, Scheaffer S, Modi Z, Kovacs A, Pietka T, DeBosch BJ, Thompson MD, Diwan A, Moley KH. A maternal high-fat, high-sucrose diet induces transgenerational cardiac mitochondrial dysfunction independently of maternal mitochondrial inheritance. Am J Physiol Heart Circ Physiol. 2019 May 1;316(5):H1202-H1210. doi: 10.1152/ajpheart.00013.2019. Epub 2019 Mar 22. PubMed PMID: 30901280.

Ma X, Mani K, Liu H, Kovacs A, Murphy JT, Foroughi L, French BA, Weinheimer CJ, Kraja A, Benjamin IJ, Hill JA, Javaheri A, Diwan A. Transcription Factor EB Activation Rescues Advanced αB-Crystallin Mutation-Induced Cardiomyopathy by Normalizing Desmin Localization. J Am Heart Assoc. 2019 Feb 19;8(4):e010866. doi: 10.1161/JAHA.118.010866. PubMed PMID: 30773991; PubMed Central PMCID: PMC6405666.

Bajpai G, Bredemeyer A, Li W, Zaitsev K, Koenig AL, Lokshina I, Mohan J, Ivey B, Hsiao HM, Weinheimer C, Kovacs A, Epelman S, Artyomov M, Kreisel D, Lavine KJ. Tissue Resident CCR2- and CCR2+ Cardiac Macrophages Differentially Orchestrate Monocyte Recruitment and Fate Specification Following Myocardial Injury. Circ Res. 2019 Jan 18;124(2):263-278. doi: 10.1161/CIRCRESAHA.118.314028. PubMed PMID: 30582448.

Boyle JJ, Soepriatna A, Damen F, Rowe RA, Pless RB, Kovacs A, Goergen CJ, Thomopoulos S, Genin GM. Regularization-Free Strain Mapping in Three Dimensions, With Application to Cardiac Ultrasound. J Biomech Eng. 2019 Jan 1;141(1). doi: 10.1115/1.4041576. PubMed PMID: 30267039; PubMed Central PMCID: PMC6298532.

Li G, Khandekar A, Yin T, Hicks SC, Guo Q, Takahashi K, Lipovsky CE, Brumback BD, Rao PK, Weinheimer CJ, Rentschler SL. Differential Wnt-mediated programming and arrhythmogenesis in right versus left ventricles. J Mol Cell Cardiol. 2018 Oct;123:92-107. doi: 10.1016/j.yjmcc.2018.09.002. Epub 2018 Sep 5. PubMed PMID: 30193957; PubMed Central PMCID: PMC6200419.

Huang Y, McClenaghan C, Harter TM, Hinman K, Halabi CM, Matkovich SJ, Zhang H, Brown GS, Mecham RP, England SK, Kovacs A, Remedi MS, Nichols CG. Cardiovascular consequences of KATP overactivity in Cantu syndrome. JCI Insight.2018 Aug 9;3(15). doi: 10.1172/jci.insight.121153. eCollection 2018 Aug 9. PubMed PMID: 30089727; PubMed Central PMCID: PMC6129117.

Knutsen RH, Beeman SC, Broekelmann TJ, Liu D, Tsang KM, Kovacs A, Ye L, Danback JR, Watson A, Wardlaw A, Wagenseil JE, Garbow JR, Shoykhet M, Kozel BA. Minoxidil improves vascular compliance, restores cerebral blood flow, and alters extracellular matrix gene expression in a model of chronic vascular stiffness. Am J Physiol Heart Circ Physiol. 2018 Jul 1;315(1):H18-H32. doi: 10.1152/ajpheart.00683.2017. Epub 2018 Mar 2. PubMed PMID: 29498532; PubMed Central PMCID: PMC6087770.

Franco A, Zhang L, Matkovich SJ, Kovacs A, Dorn GW 2nd. G-protein receptor kinases 2, 5 and 6 redundantly modulate Smoothened-GATA transcriptional crosstalk in fetal mouse hearts. J Mol Cell Cardiol. 2018 Aug;121:60-68. doi: 10.1016/j.yjmcc.2018.06.009. Epub 2018 Jun 30. PubMed PMID: 29969579; PubMed Central PMCID: PMC6178805.

Liss KHH, McCommis KS, Chambers KT, Pietka TA, Schweitzer GG, Park SL, Nalbantoglu I, Weinheimer CJ, Hall AM, Finck BN. The impact of diet-induced hepatic steatosis in a murine model of hepatic ischemia/reperfusion injury. Liver Transpl. 2018 Jul;24(7):908-921. doi: 10.1002/lt.25189. PubMed PMID: 29729104; PubMed Central PMCID: PMC6097916.

Adamo L, Staloch LJ, Rocha-Resende C, Matkovich SJ, Jiang W, Bajpai G, Weinheimer CJ, Kovacs A, Schilling JD, Barger PM, Bhattacharya D, Mann DL. Modulation of subsets of cardiac B lymphocytes improves cardiac function after acute injury. JCI Insight. 2018 Jun 7;3(11). doi: 10.1172/jci.insight.120137. eCollection 2018 Jun 7. PubMed PMID: 29875326; PubMed Central PMCID: PMC6124442.

Weinheimer CJ, Kovacs A, Evans S, Matkovich SJ, Barger PM, Mann DL. Load-Dependent Changes in Left Ventricular Structure and Function in a Pathophysiologically Relevant Murine Model of Reversible Heart Failure. Circ Heart Fail. 2018 May;11(5):e004351. doi: 10.1161/CIRCHEARTFAILURE.117.004351. PubMed PMID: 29716898; PubMed Central PMCID: PMC5935139.

Heitmeier MR, Payne MA, Weinheimer C, Kovacs A, Hresko RC, Jay PY, Hruz PW. Metabolic and Cardiac Adaptation to Chronic Pharmacologic Blockade of Facilitative Glucose Transport in Murine Dilated Cardiomyopathy and Myocardial Ischemia. Sci Rep. 2018 Apr 24;8(1):6475. doi: 10.1038/s41598-018-24867-1. PubMed PMID: 29691457; PubMed Central PMCID: PMC5915485.

Evans S, Tzeng HP, Veis DJ, Matkovich S, Weinheimer C, Kovacs A, Barger PM, Mann DL. TNF receptor-activated factor 2 mediates cardiac protection through noncanonical NF-κB signaling. JCI Insight. 2018 Feb 8;3(3). doi: 10.1172/jci.insight.98278. eCollection 2018 Feb 8. PubMed PMID: 29415884; PubMed Central PMCID: PMC5821173.

Jagger BW, Miner JJ, Cao B, Arora N, Smith AM, Kovacs A, Mysorekar IU, Coyne CB, Diamond MS. Gestational Stage and IFN-λ Signaling Regulate ZIKV Infection In Utero. Cell Host Microbe. 2017 Sep 13;22(3):366-376.e3. doi: 10.1016/j.chom.2017.08.012. PubMed PMID: 28910635; PubMed Central PMCID: PMC5647680.

Khandekar A, Springer S, Wang W, Hicks S, Weinheimer C, Diaz-Trelles R, Nerbonne JM, Rentschler S. Notch-Mediated Epigenetic Regulation of Voltage-Gated Potassium Currents. Circ Res. 2016 Dec 9;119(12):1324-1338. doi: 10.1161/CIRCRESAHA.116.309877. Epub 2016 Oct 3. PubMed PMID: 27697822; PubMed Central PMCID: PMC5148677.

Moon SH, Mancuso DJ, Sims HF, Liu X, Nguyen AL, Yang K, Guan S, Dilthey BG, Jenkins CM, Weinheimer CJ, Kovacs A, Abendschein D, Gross RW. Cardiac Myocyte-specific Knock-out of Calcium-independent Phospholipase A2γ (iPLA2γ) Decreases Oxidized Fatty Acids during Ischemia/Reperfusion and Reduces Infarct Size. J Biol Chem. 2016 Sep 9;291(37):19687-700. doi: 10.1074/jbc.M116.740597. Epub 2016 Jul 23. PubMed PMID: 27453526; PubMed Central PMCID: PMC5016701.

Lampropoulou V, Sergushichev A, Bambouskova M, Nair S, Vincent EE, Loginicheva E, Cervantes-Barragan L, Ma X, Huang SC, Griss T, Weinheimer CJ, Khader S, Randolph GJ, Pearce EJ, Jones RG, Diwan A, Diamond MS, Artyomov MN. Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation. Cell Metab. 2016 Jul 12;24(1):158-66. doi: 10.1016/j.cmet.2016.06.004. Epub 2016 Jun 30. PubMed PMID: 27374498; PubMed Central PMCID: PMC5108454.

Miller JR, Henn MC, Lancaster TS, Lawrance CP, Schuessler RB, Shepard M, Anderson M, Kovacs A, Matheny RG, Eghtesady P, Damiano RJ, Boston US. Pulmonary Valve Replacement With Small Intestine Submucosa-Extracellular Matrix in a Porcine Model. World J Pediatr Congenit Heart Surg. 2016 Jul;7(4):475-83. doi: 10.1177/2150135116651113. PubMed PMID: 27358303.

Levin MD, Singh GK, Zhang HX, Uchida K, Kozel BA, Stein PK, Kovacs A, Westenbroek RE, Catterall WA, Grange DK, Nichols CG. K(ATP) channel gain-of-function leads to increased myocardial L-type Ca(2+) current and contractility in Cantu syndrome. Proc Natl Acad Sci U S A. 2016 Jun 14;113(24):6773-8. doi: 10.1073/pnas.1606465113. Epub 2016 May 31. PubMed PMID: 27247394; PubMed Central PMCID: PMC4914204.

Topkara VK, Chambers KT, Yang KC, Tzeng HP, Evans S, Weinheimer C, Kovacs A, Robbins J, Barger P, Mann DL. Functional significance of the discordance between transcriptional profile and left ventricular structure/function during reverse remodeling. JCI Insight. 2016 Apr 6;1(4):e86038. doi: 10.1172/jci.insight.86038. PubMed PMID: 27158672; PubMed Central PMCID: PMC4855517.

House SL, Castro AM, Lupu TS, Weinheimer C, Smith C, Kovacs A, Ornitz DM. Endothelial fibroblast growth factor receptor signaling is required for vascular remodeling following cardiac ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2016 Mar 1;310(5):H559-71. doi: 10.1152/ajpheart.00758.2015. Epub 2016 Jan 8. PubMed PMID: 26747503; PubMed Central PMCID: PMC4796602.

Cheng SL, Ramachandran B, Behrmann A, Shao JS, Mead M, Smith C, Krchma K, Bello Arredondo Y, Kovacs A, Kapoor K, Brill LM, Perera R, Williams BO, Towler DA. Vascular smooth muscle LRP6 limits arteriosclerotic calcification in diabetic LDLR-/- mice by restraining noncanonical Wnt signals. Circ Res. 2015 Jul 3;117(2):142-56. doi: 10.1161/CIRCRESAHA.117.306712. Epub 2015 Jun 1. PubMed PMID: 26034040; PubMed Central PMCID: PMC4490945.

Zhang W, Lavine KJ, Epelman S, Evans SA, Weinheimer CJ, Barger PM, Mann DL. Necrotic myocardial cells release damage-associated molecular patterns that provoke fibroblast activation in vitro and trigger myocardial inflammation and fibrosis in vivo. J Am Heart Assoc. 2015 Jun 2;4(6):e001993. doi: 10.1161/JAHA.115.001993. PubMed PMID: 26037082; PubMed Central PMCID: PMC4599537.

Ma X, Liu H, Murphy JT, Foyil SR, Godar RJ, Abuirqeba H, Weinheimer CJ, Barger PM, Diwan A. Regulation of the transcription factor EB-PGC1α axis by beclin-1 controls mitochondrial quality and cardiomyocyte death under stress. Mol Cell Biol. 2015 Mar;35(6):956-76. doi: 10.1128/MCB.01091-14. Epub 2015 Jan 5. PubMed PMID: 25561470; PubMed Central PMCID: PMC4333088.

House SL, Wang J, Castro AM, Weinheimer C, Kovacs A, Ornitz DM. Fibroblast growth factor 2 is an essential cardioprotective factor in a closed-chest model of cardiac ischemia-reperfusion injury. Physiol Rep. 27;3(1), 2015. PMID: 25626875

Weinheimer CJ, Lai L, Kelly DP, Kovacs A. Novel mouse model of left ventricular pressure overload and infarction causing predictable ventricular remodelling and progression to heart failure. Clin Exp Pharmacol Physiol. 42(1):33-40, 2015. PMID: 25311547

Schugar RC, Moll AR, Andre d’Avignon D, Weinheimer CJ, Kovacs A, Crawford PA. Cardiomyocyte-specific deficiency of ketone body metabolism promotes accelerated pathological remodeling. Mol Metab. 13;3(7):754-69, 2014 PMID:25353003

Cilvik SN, Wang JI, Lavine KJ, Uchida K, Castro A, Gierasch CM, Weinheimer CJ, House SJ, Kovacs A, Nichols CG, Ornitz DM. Fibroblast growth factor receptor 1 signaling in adult cardiomyocytes increases contactility and results in a hypertrophic cardiomyopathy. PLoS One. 11;8(12):e82979, 2013 PMID:24349409

Lavine KJ, Kovacs A, Weinheimer C, Mann DL. Repetitive myocardial ischemia promotes coronary growth in the adult mammalian heart. J Am Heart Assoc. 30;2 (5):e000343, 2013. PMID:24080909

Sondergaard CS, Hess DA, Maxwell DJ, Weinheimer C, Rosova I, Creer MH, Piwnica-Worms D, Kovacs A, Pederson L, Nolta JA. Human cord blood progenitors with high aldehyde dehydrogenase activity improve vascular density in a model of acute myocardial infarction. J Transl Med 9;8:24, 2010 PMID:20214792

Schaeffer PJ, Desantiago J, Yang J, Flagg TP, Kovacs A, Weinheimer CJ, Courtois M, Leone TC, Nichols CG, Bers DM, Kelly DP. Impaired contractile function and calcium handling in hearts of cardiac-specific calcineurin b1-deficient mice. Am J Physiol Heart Circ Physiol. 297(4), 2009 PMID:19700627

Flagg TP, Cazorla O, Remedi MS, Haim TE, Tones MA, Bahinski A, Numann RE, Kovacs A, Schaffer JE, Nichols CG, Nerbonne JM. Ca2+-Independent alterations in diastolic sarcomere length and relaxation kinetics in a mouse model of lipotoxic diabetic cardiomyopathy. Circ Res. Jan 2;104(1):95-103, 2009.

Galvin N, Vogler C, Levy B, Kovacs A, Griffey M, Sands M. A murine model of infantile neuronal ceroid lipofuscinosis – Ultrastructural evaluation of storage in the central nervous system and viscera. Pediatr Dev Pathol. 11:185-92, 2008.

Lai L, Leone TC, Zechner C, Schaeffer PJ, Kelly SM, Flanagan DP, Medeiros DM, Kovacs A, Kelly DP. Transcriptional coactivators PGC-1alpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart. Genes Dev. 15;22:1948-61, 2008.

Lavine KJ, Kovacs A, Ornitz DM. Hedgehog signaling is critical for maintenance of the adult coronary vasculature in mice. J Clin Invest.118:2404-14, 2008.

Ma X, Tittiger M, Knutsen RH, Kovacs A, Schaller L, Mecham RP, Ponder KP. Upregulation of elastase proteins results in aortic dilatation in mucopolysaccharidosis I mice. Mol Genet Metab. 94:298-304, 2008.

Sedaghat Herati R, Ma X, Tittiger M, Ohlemiller KK, Kovacs A, Ponder KP. Improved retroviral vector design results in sustained expression after adult gene therapy in mucopolysaccharidosis I mice. J Gene Med. 10:972-982, 2008.

Shoghi KI, Gropler RJ, Sharp T, Herrero P, Fettig N, Su Y, Mitra MS, Kovacs A, Finck BN, Welch MJ. Time course of alterations in myocardial glucose utilization in the Zucker diabetic fatty rat with correlation to gene expression of glucose transporters: A small-animal PET investigation. J Nucl Med. 49:1320-1327, 2008.

Flagg TP, Patton B, Masia R, Mansfield C, Lopatin AN, Yamada KA, Nichols CG. Arrhythmia susceptibility and premature death in transgenic mice overexpressing both SUR1 and Kir6.2[ΔN30,K185Q] in the heart. Am J Physiol 293:H836-H845, 2007.

Huss JM, Imahashi K, Dufour CR, Weinheimer CJ, Courtois M, Kovacs A, Giguère V, Murphy E, Kelly DP: The nuclear receptor ERRα is required for the bioenergetic and functional adaptation to cardiac pressure overload. Cell Met. 6:25-37, 2007.

Lau JM, Jin X, Ren J, Avery J, DeBosch BJ, Treskov I, Lupu TS, Kovacs A, Weinheimer C, Muslin AJ. The 14-3-3tau phosphoserine-binding protein is required for cardiomyocyte survival. Mol Cell Biol. Feb;27(4):1455-66, 2007. Epub 2006 Dec 4. PMID: 17145769 [PubMed – indexed for MEDLINE]

Ma X, Liu Y, Tittiger M, Hennig A, Kovacs A, Popelka S, Wang B, Herati R, Bigg M, Ponder KP. Improvements in mucopolysaccharidosis I mice after adult retroviral vector-mediated gene therapy with immunomodulation. Mol Ther. Feb 20; [Epub ahead of print] PMID: 17311010, 2007 [PubMed – as supplied by publisher]

Piel DA, Gruber PJ, Weinheimer CJ, Courtois MR, Robertson CM, Coopersmith CM, Deutschman CS, Levy RJ: Mitochondrial resuscitation with exogenouscytochrome c in the septic heart, >Critical Care Medicine. 35(9):2120-2127, September 2007

Yang J, Sambandam N, Han X, Gross RW, Courtois M, Kovacs A, Febbraio M, Finck BN, Kelly DP. CD36 deficiency rescues lipotoxic cardiomyopathy.Circ Res. Mar 15; [Epub ahead of print] PMID: 17363697, 2007 [PubMed – as supplied by publisher]

DeBosch B, Sambandam N, Weinheimer C, Courtois M, Muslin AJ. Akt2 regulates cardiac metabolism and cardiomyocyte survival.J Biol Chem. Oct 27;281(43):32841-51, 2006. Epub 2006 Aug 31. PMID: 16950770 [PubMed – indexed for MEDLINE]

DeBosch B, Treskov I, Lupu TS, Weinheimer C, Kovacs A, Courtois M, Muslin AJ.
Akt1 is required for physiological cardiac growth. Circulation May 2;113(17):2097-104, 2006. Epub 2006 Apr 24. PMID: 16636172 [PubMed – indexed for MEDLINE]

Chiu HC, Kovacs A, Blanton RM, Han X, Courtois M, Weinheimer CJ, Yamada KA, Brunet S, Xu H, Nerbonne JM, Welch MJ, Fettig NM, Sharp TL, Sambandam N, Olson KM, Ory DS, Schaffer JE. Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy. Circ Res. Feb 4;96(2):225-33, 2005. Epub 2004 Dec 23. PMID: 15618539 [PubMed – indexed for MEDLINE]

Holland MR, Kovacs A, Posdamer SH, Wallace KD, Miller JG. Anisotropy of apparent backscatter in the short-axis view of mouse hearts. Ultrasound Med Biol. Dec;31(12):1623-9, 2005. PMID: 16344125 [PubMed – indexed for MEDLINE]